Publications

Selected Publications

Wulf & Pless; “High-sensitivity fluorometry to resolve ion channel conformational dynamics”; 2018, Cell Reports

Lynagh et al.; “A selectivity filter at the intracellular end of the acid-sensing ion channel pore”; 2017, eLife

Kim et al., “Atomic basic for therapeutic activation of neuronal potassium channels”; 2015, Nature Communications

Pless et al., “Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels”; 2013, eLife

Pless et al., “A novel mechanism for fine-tuning open state stability in a voltage-gated potassium channel”; 2013, Nature Communications

Pless et al., “Contributions of counter charge in a potassium channel voltage sensor”, 2011, Nature Chemical Biology

Left: Top down view of a Cys-loop receptor

 

2018

Chua, H.C., Servatius, H., Asatryan, B., Schaller, A.,  Rieubland, C., Noti, F., Seiler, J., Roten, L., Baldinger, S.H., Tanner, H., Fuhrer, J., Haeberlin, A., Lam, A., Pless, S.A., Medeiros-Domingo, A.; “Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results”; Clinical Research in Cardiology [PubMed]

Khoo, K.K. & Pless, S.A.; “How an intrinsic ligand tunes the activity of a potassium channel”; Journal of General Physiology [PubMed]

Servatius, H., Porro, A., Pless, S.A., Schaller, A., Asatryan, B., Tanner, H., de Marchi, S.F., Roten, L., Seiler, J., Haeberlin, A., Baldinger, S.H., Noti, F., Lam, A., Fuhrer, J., Moroni, A., Medeiros-Domingo, A.; “Phenotypic spectrum of HCN4 mutations”; Circulation: Genomic and Precision Medicine [PubMed]

Wulf, M. & Pless, S.A.; “High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics”; Cell Reports [PubMed]

Callau-Vazquez, D., Pless, S.A., Lynagh, T.; “Investigation of agonist recognition and channel properties in a flatworm glutamate-gated chloride channel”; Biochemistry [PubMed]

Pless, S.A. & Sivilotti, L.G.; “A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins”; Current Opinion in Physiology [Link]

2017

Kim, R.Y., Pless, S.A., Kurata, H.T.; “PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels”; Proc Nat Acad Sci (PNAS) [PubMed]

Lynagh, T., Romero-Rojo, J.L., Lund, C., Pless, S.A.; “Molecular basis for allosteric inhibition of acid-sensing ion channel 1a by ibuprofen”; Journal of Medicinal Chemistry [PubMed]

Lynagh, T.,  Flood, E.,  Boiteux, C., Wulf, M., Komnatnyy, V.V., Colding, J.M., Allen, T.W., Pless, S.A.; “A selectivity filter at the intracellular end of the acid-sensing ion channel pore”; eLife [PubMed]

Lynagh, T., Komnatnyy, V.V., Pless, S.A.; “Unique contributions of an arginine side chain to ligand-recognition in a glutamate-gated chloride channcel”; The Journal of Biological Chemistry [PubMed]

2016

Braun, N., Lynagh, T., Yu, R., Biggin, P.C., Pless, S.A.; “The role of an absolutely conserved tryptophan pair in the extracellular domain of Cys-loop receptors”; ACS Chemical Neuroscience [PubMed]

2015

Pless, S.A. & Ahern, C.A.; “Applying chemical biology to ion channels”; Adv Exp Med Biol (Springer book) [PubMed]

Kim, R.Y., Yau M.C., Galpin J.D., Seebohm G., Ahern, C.A., Pless, S.A., Kurata, H.T., ; “Atomic basis for therapeutic activation of neuronal potassium channels”; Nature Communications [PubMed]

Zhang, R.S., Wright, J., Pless, S.A., Nunez, J.J., Kim, R.Y., Li, J.B., Yang, R., Ahern, C.A., Kurata, H.T., ; “A conserved residue cluster that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Kim, R., Ahern, C.A., Kurata, H.T., ; “Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology”; Journal of Physiology [PubMed]

2014

Pless, S.A.; “Caught in the act: mutliple binding sites for memantine”; Structure [PubMed]

Lynagh, T. & Pless, S.A.; “Principles of agonist recognition in Cys-loop receptors”; Frontiers in Physiology [PubMed]

Pless, S.A., Elstone, F.D., Niciforovic, A.P., Galpin, J.D., Yang, R., Kurata, H.T., Ahern, C.A.; “Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains”; The Journal of General Physiology [PubMed]

2013

Pless, S.A., Galpin, J.D., Niciforovic, A.P., Kurata, H.T., Ahern, C.A.; “Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels”; eLife [PubMed]

Pless, S.A., Niciforovic, A.P., Nunez, J.J., Galpin, J.D., Kurata, H.T., Ahern, C.A.; “A novel mechanism for fine-tuning open state stability in a voltage-gated potassium channel”; Nature Communications [PubMed]

Pless, S.A. & Ahern, C.A.; “Probing ligand receptor interactions with unnatural amino acids”; Annual Review of Pharmacology and Toxicology [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Schwarz, S.K., Ahern, C.A.; “Expression-dependent pharmacology of TRPV1 in Xenopus laevis oocytes”; Channels [PubMed]

2012

Lacroix, J.J., Pless, S.A., Maragliano, L., Campos, F.V., Galpin, J.D., Ahern, C.A., Roux, B., Bezanilla, F.; “Intermediate state trapping of a voltage sensor”; The Journal of General Physiology [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Schwarz, S.K., Ahern, C.A.; ”Extracellular quarternary ammonium blockade of transient receptor vanilloid subtype 1 channels expressed in Xenopus laevis oocytes”; Molecular Pharmacology [PubMed]

2011

Pless, S.A.*, Leung, A., Galpin, J.D., Ahern, C.A.; ”Contributions of conserved residues at the gating interface of glycine receptors”, *-corresponding author, The Journal of Biological Chemistry [PubMed]

Pless, S.A., Galpin, J.D., Niciforovic, A, Ahern, C.A.; “Contributions of counter charge in a potassium channel voltage sensor”, Nature Chemical Biology [PubMed]

Pless, S.A., Galpin, J.D., Frankel, A., Ahern, C.A.; “Molecular basis for inhibition of cardiac sodium channels by class Ib anti-arrythmics”; Nature Communications [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Ahern, C.A., Schwarz, S.K.; “The quaternary lidocaine derivative, QX-314, exerts biphasic effects on TRPV1 channels in vitro”, Anesthesiology [PubMed]

Pless, S.A., Hanek, A.P., Lynch, J.W., Lester, H.A., Dougherty, D.A., Lummis, S.C.; “A cation-pi interaction in the glycine receptor binding site is conserved for different agonists”, Molecular Pharmacology [PubMed]

2009/2010

Wang, Q., Pless, S.A., Lynch J.W.; “Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of alpha 1, beta 2, gamma 2 GABA-A receptors”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch J.W.; “The magnitude of a conformational change in the glycine receptor beta1- beta2 loop is correlated with agonist efficacy”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch, J.W.; “Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch, J.W.; “Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits”; Journal of Neurochemistry [PubMed]

2007/2008

Pless, S.A., Millen, K.S., Hanek, A.P., Lynch, J.W., Lester, H.A., Dougherty, D.A., Lummis, S.C.; “A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue”, Journal of Neuroscience [PubMed]

Pless, S.A., Lynch, J.W.; “Illuminating the structure and function of Cys-loop receptors”; Clinical and Experimental Physiology and Pharmacology [PubMed]

Pless, S.A., Dibas, M.I., Lester, H.A., Lynch, J.W.;
“Conformational variability of the glycine receptor M2 domain in response to activation by different agonists”; The Journal of Biological Chemistry [PubMed]