Publications

Selected Publications

Lynagh et al.; “A selectivity filter at the intracellular end of the acid-sensing ion channel pore”; 2017, eLife

Kim et al., “Atomic basic for therapeutic activation of neuronal potassium channels”; 2015, Nature Communications

Pless et al., “Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels”; 2013, eLife

Pless et al., “A novel mechanism for fine-tuning open state stability in a voltage-gated potassium channel”; 2013, Nature Communications

Pless et al., “Contributions of counter charge in a potassium channel voltage sensor”, 2011, Nature Chemical Biology

Pless et al., “Molecular basis for inhibition of cardiac sodium channels by class Ib anti-arrhythmics”; 2011, Nature Communications 

Left: Top down view of a Cys-loop receptor

 

2017

Kim, R.Y., Pless, S.A., Kurata, H.T.; “PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels”; Proc Nat Acad Sci (PNAS) [PubMed]

Lynagh, T., Romero-Rojo, J.L., Lund, C., Pless, S.A.; “Molecular basis for allosteric inhibition of acid-sensing ion channel 1a by ibuprofen”; Journal of Medicinal Chemistry [PubMed]

Lynagh, T.,  Flood, E.,  Boiteux, C., Wulf, M., Komnatnyy, V.V., Colding, J.M., Allen, T.W., Pless, S.A.; “A selectivity filter at the intracellular end of the acid-sensing ion channel pore”; eLife [PubMed]

Lynagh, T., Komnatnyy, V.V., Pless, S.A.; “Unique contributions of an arginine side chain to ligand-recognition in a glutamate-gated chloride channcel”; The Journal of Biological Chemistry [PubMed]

2016

Braun, N., Lynagh, T., Yu, R., Biggin, P.C., Pless, S.A.; “The role of an absolutely conserved tryptophan pair in the extracellular domain of Cys-loop receptors”; ACS Chemical Neuroscience [PubMed]

2015

Pless, S.A. & Ahern, C.A.; “Applying chemical biology to ion channels”; Adv Exp Med Biol (Springer book) [PubMed]

Kim, R.Y., Yau M.C., Galpin J.D., Seebohm G., Ahern, C.A., Pless, S.A., Kurata, H.T., ; “Atomic basis for therapeutic activation of neuronal potassium channels”; Nature Communications [PubMed]

Zhang, R.S., Wright, J., Pless, S.A., Nunez, J.J., Kim, R.Y., Li, J.B., Yang, R., Ahern, C.A., Kurata, H.T., ; “A conserved residue cluster that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Kim, R., Ahern, C.A., Kurata, H.T., ; “Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology”; Journal of Physiology [PubMed]

2014

Pless, S.A.; “Caught in the act: mutliple binding sites for memantine”; Structure [PubMed]

Lynagh, T. & Pless, S.A.; “Principles of agonist recognition in Cys-loop receptors”; Frontiers in Physiology [PubMed]

Pless, S.A., Elstone, F.D., Niciforovic, A.P., Galpin, J.D., Yang, R., Kurata, H.T., Ahern, C.A.; “Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains”; The Journal of General Physiology [PubMed]

2013

Pless, S.A., Galpin, J.D., Niciforovic, A.P., Kurata, H.T., Ahern, C.A.; “Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels”; eLife [PubMed]

Pless, S.A., Niciforovic, A.P., Nunez, J.J., Galpin, J.D., Kurata, H.T., Ahern, C.A.; “A novel mechanism for fine-tuning open state stability in a voltage-gated potassium channel”; Nature Communications [PubMed]

Pless, S.A. & Ahern, C.A.; “Probing ligand receptor interactions with unnatural amino acids”; Annual Review of Pharmacology and Toxicology [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Schwarz, S.K., Ahern, C.A.; “Expression-dependent pharmacology of TRPV1 in Xenopus laevis oocytes”; Channels [PubMed]

2012

Lacroix, J.J., Pless, S.A., Maragliano, L., Campos, F.V., Galpin, J.D., Ahern, C.A., Roux, B., Bezanilla, F.; “Intermediate state trapping of a voltage sensor”; The Journal of General Physiology [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Schwarz, S.K., Ahern, C.A.; ”Extracellular quarternary ammonium blockade of transient receptor vanilloid subtype 1 channels expressed in Xenopus laevis oocytes”; Molecular Pharmacology [PubMed]

2011

Pless, S.A.*, Leung, A., Galpin, J.D., Ahern, C.A.; ”Contributions of conserved residues at the gating interface of glycine receptors”, *-corresponding author, The Journal of Biological Chemistry [PubMed]

Pless, S.A., Galpin, J.D., Niciforovic, A, Ahern, C.A.; “Contributions of counter charge in a potassium channel voltage sensor”, Nature Chemical Biology [PubMed]

Pless, S.A., Galpin, J.D., Frankel, A., Ahern, C.A.; “Molecular basis for inhibition of cardiac sodium channels by class Ib anti-arrythmics”; Nature Communications [PubMed]

Rivera-Aceveda, R.E., Pless, S.A., Ahern, C.A., Schwarz, S.K.; “The quaternary lidocaine derivative, QX-314, exerts biphasic effects on TRPV1 channels in vitro”, Anesthesiology [PubMed]

Pless, S.A., Hanek, A.P., Lynch, J.W., Lester, H.A., Dougherty, D.A., Lummis, S.C.; “A cation-pi interaction in the glycine receptor binding site is conserved for different agonists”, Molecular Pharmacology [PubMed]

2009/2010

Wang, Q., Pless, S.A., Lynch J.W.; “Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of alpha 1, beta 2, gamma 2 GABA-A receptors”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch J.W.; “The magnitude of a conformational change in the glycine receptor beta1- beta2 loop is correlated with agonist efficacy”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch, J.W.; “Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain”; The Journal of Biological Chemistry [PubMed]

Pless, S.A., Lynch, J.W.; “Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits”; Journal of Neurochemistry [PubMed]

2007/2008

Pless, S.A., Millen, K.S., Hanek, A.P., Lynch, J.W., Lester, H.A., Dougherty, D.A., Lummis, S.C.; “A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue”, Journal of Neuroscience [PubMed]

Pless, S.A., Lynch, J.W.; “Illuminating the structure and function of Cys-loop receptors”; Clinical and Experimental Physiology and Pharmacology [PubMed]

Pless, S.A., Dibas, M.I., Lester, H.A., Lynch, J.W.;
“Conformational variability of the glycine receptor M2 domain in response to activation by different agonists”; The Journal of Biological Chemistry [PubMed]