The title is already quite the mouthful, but the conference keeps living up to it: a great mix of ion channelologists, transporter people and folks working on pumps mix and mingle for a week under the Californian sun. The highlights were some exciting posters on unatural amino acid incorporation and a few outstanding talks on new horizons in structural biology – looking forward to the 2016 edition (rumor has it the next one will be held in Spain)