Check out our latest manuscript on bioRxiv, in which we outline how and where the neuropetide big dynorphin exerts its effects on ASIC1a. For this project, we have employed the widest array of approaches to date, including electrophysiology, voltage-clamp fluorometry, peptide synthesis, CRISPR and non-canonical amino acids cross linkers. Congratulations to our former PhD students (now postdocs) Christian and Nina and the rest of the team that contributed to this grand effort – in particular to our collaborators from the Bennett and Strømgaard groups.
