Huge thanks to postdoc Chow and the rest of the NALCN team for their epic efforts to put this manuscript together. We demonstrate how the elusive sodium leak channel requires the presence of three other neuronal proteins to be robustly expressed in heterologous systems. We then go on to show that its constitutive activity is modulated by both voltage and extracellular divalent cations, in particular calcium. All the details to be found on here. We are very grateful for the support from the Danish Research Council, the Carlsberg Foundation and the Lundbeck Foundation.
