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Toronto 2023

Stephan was hosted by Lundbeck Foundation Collaborative Grant collaborator Prof Mei Zhen at the Lunenfeld-Tanenbaum Research Institute, before visiting Adriano Senatore at the University of Toronto Mississauga, as well as a short stint at ProteinQure. Big thanks to the hosts and to everyone involved for inspiring discussions and input.

New preprint on NALCN pharmacology

NALCN is notorious for its resilience towards pharmacological manipulation. In our latest preprint, we find that unplugging DI-DIV and DII-DIII lateral fenestrations reveals an unexpected pharmacology. All credit goes to former MSc student Katharina Schott and to former postdoc Han Chow Chua, now lecturer at the University of Sydney, for leading this project. The full story can be found HERE.

Tim in town

4 years after his move to Bergen, Norway to set up his own lab, we had the pleasure of hosting Pless lab alumus Timothy Lynagh. It was great to have him in town and to hear about all the cool ion channel work they have going on up there near the Polar Circle! Thanks for swinging by, Tim, and very nice to see your lab doing so well!

Genetic code expansion talk

Stephan was fortunate enough to be invited to contribute to the virtual genetic code expansion (GCE) seminar series. This was a welcome opportunity to share some of our recent efforts on introduction of non-canonical amino acids into ASICs. A recording of the talk can be found HERE.

Welcome back!

Stephanie returns from maternity leave to re-join our efforts on ASIC, while Emma starts her PhD work on NALCN. Welcome back and we hugely look forward to having you around (again)!

Biophysics 2023

Caroline, Hendrik, Mette, Sam and Stephan ventured to the annual geek fest, which was hosted in San Diego this year. Great opportunity to showcase some of our ongoing ASIC and NALCN work – and to connect with friends and colleagues, both old and new!

Two Marie Curie Fellowships

Delighted to share the news that we will have two incoming Marie Curie Postdoc fellows this year! Nadine Ritter will re-join the lab to work on NALCN and Laurie Peverini will start working on splicing in Nav1.5 – big congratulations to both and we look forward to having you around from later in the year!

More newcomers

Victor is a MSc student that will team up with Sam (and Alex Hauser) to work on computational approaches on the NALCN complex and Mikkel is a project student who will join Mette in her quest to unravel the functional consequences of protein-protein interactions in ligand-gated ion channels.

Hello and farewell

Time to say a big thank you to Fadumo, who has been a terrific lab tech intern over the past year. Your help was greatly appreciated and we wish you all the best for the future. At the same time, we welcome Hanna to the team, who will be our lab tech intern for the next 12 months – we look forward to having you around!