We were lucky enough to be able to spend the 2018 edition of our annual lab retreat at Lake Como, Italy. Although our lodgings were not quite as fancy as George Clooney´s famous lakeside estate only meters further down the road, we greatly enjoyed our two days of science presentations and hikes. Thanks to the advice and planning by local and former PhD student Federica, we were treated to great food and superb views – while also brushing up on a lot of the technologies used in the lab (e.g. obsessing over Western blots, series resistance compensation and color palettes). Thanks everyone for making it a productive and fun outing!